T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry

T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca(2+) to activate the key transcription factors nuclear factor of activated T lymphocytes (NFAT) and NF-κB. The mechanism of NFAT activation by Ca(2+) has been determined. However, th...

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Udgivet i:J Biol Chem
Main Authors: Liu, Xiaohong, Berry, Corbett T., Ruthel, Gordon, Madara, Jonathan J., MacGillivray, Katelyn, Gray, Carolyn M., Madge, Lisa A., McCorkell, Kelly A., Beiting, Daniel P., Hershberg, Uri, May, Michael J., Freedman, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861418/
https://ncbi.nlm.nih.gov/pubmed/26826124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713008
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