Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 p...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Chelko, Stephen P., Asimaki, Angeliki, Andersen, Peter, Bedja, Djahida, Amat-Alarcon, Nuria, DeMazumder, Deeptankar, Jasti, Ravirasmi, MacRae, Calum A., Leber, Remo, Kleber, Andre G., Saffitz, Jeffrey E., Judge, Daniel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861310/
https://ncbi.nlm.nih.gov/pubmed/27170944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85923
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