Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 p...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Chelko, Stephen P., Asimaki, Angeliki, Andersen, Peter, Bedja, Djahida, Amat-Alarcon, Nuria, DeMazumder, Deeptankar, Jasti, Ravirasmi, MacRae, Calum A., Leber, Remo, Kleber, Andre G., Saffitz, Jeffrey E., Judge, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861310/
https://ncbi.nlm.nih.gov/pubmed/27170944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85923
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