Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 p...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Chelko, Stephen P., Asimaki, Angeliki, Andersen, Peter, Bedja, Djahida, Amat-Alarcon, Nuria, DeMazumder, Deeptankar, Jasti, Ravirasmi, MacRae, Calum A., Leber, Remo, Kleber, Andre G., Saffitz, Jeffrey E., Judge, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861310/
https://ncbi.nlm.nih.gov/pubmed/27170944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85923
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