Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 p...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Chelko, Stephen P., Asimaki, Angeliki, Andersen, Peter, Bedja, Djahida, Amat-Alarcon, Nuria, DeMazumder, Deeptankar, Jasti, Ravirasmi, MacRae, Calum A., Leber, Remo, Kleber, Andre G., Saffitz, Jeffrey E., Judge, Daniel P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861310/
https://ncbi.nlm.nih.gov/pubmed/27170944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85923
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