Design of potent, proteolytically stable oxyntomodulin analogs

Incretin-based peptides are effective therapeutics for treating type 2 diabetes mellitus (T2DM). Oxyntomodulin (OXM), a dual agonist of GLP-1R and GCGR, has shown superior weight loss and glucose lowering effects, compared to single GLP-1R agonists. To overcome the short half-life and rapid renal cl...

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Pubblicato in:ACS Chem Biol
Autori principali: Muppidi, Avinash, Zou, Huafei, Yang, Peng Yu, Chao, Elizabeth, Sherwood, Lance, Nunez, Vanessa, Woods, Ashley, Schultz, Peter G, Lin, Qing, Shen, Weijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861236/
https://ncbi.nlm.nih.gov/pubmed/26727558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00787
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