Apolipoprotein A-I coating of protamine–oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood–brain barrier

Drug delivery to the brain is severely restricted by formation of tight junctions between adjacent brain capillary endothelial cells (BCEC). In the present study we have evaluated the effects of protamine–oligonucleotide nanoparticles (proticles) on the functional properties of primary porcine BCEC...

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Библиографические подробности
Опубликовано в: :J Control Release
Главные авторы: Kratzer, Ingrid, Wernig, Karin, Panzenboeck, Ute, Bernhart, Eva, Reicher, Helga, Wronski, Robert, Windisch, Manfred, Hammer, Astrid, Malle, Ernst, Zimmer, Andreas, Sattler, Wolfgang
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861216/
https://ncbi.nlm.nih.gov/pubmed/17239472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2006.11.020
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