Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro

Recent observations link myeloperoxidase (MPO) activation to neurodegeneration. In multiple sclerosis MPO is present in areas of active demyelination where the potent oxidant hypochlorous acid (HOCl), formed by MPO from H(2)O(2) and chloride ions, could oxidatively damage myelin-associated lipids. T...

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Bibliografische gegevens
Hoofdauteurs: Nusshold, Christoph, Kollroser, Manfred, Köfeler, Harald, Rechberger, Gerald, Reicher, Helga, Üllen, Andreas, Bernhart, Eva, Waltl, Sabine, Kratzer, Ingrid, Hermetter, Albin, Hackl, Hubert, Trajanoski, Zlatko, Hrzenjak, Andelko, Malle, Ernst, Sattler, Wolfgang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061462/
https://ncbi.nlm.nih.gov/pubmed/20226853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.037
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