Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particular sphingosine-1-phosphate (S1P) and the...

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Udgivet i:Biochem Pharmacol
Main Authors: Bernhart, Eva, Damm, Sabine, Wintersperger, Andrea, Nusshold, Christoph, Brunner, Anna Martina, Plastira, Ioanna, Rechberger, Gerald, Reicher, Helga, Wadsack, Christian, Zimmer, Andreas, Malle, Ernst, Sattler, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490581/
https://ncbi.nlm.nih.gov/pubmed/26002572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.05.007
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