Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

During inflammation, activated leukocytes release cytotoxic mediators that compromise blood–brain barrier (BBB) function. Under inflammatory conditions, myeloperoxidase (MPO) is critically involved in inflicting BBB damage. We used genetic and pharmacological approaches to investigate whether MPO in...

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Udgivet i:Int J Mol Sci
Main Authors: Goeritzer, Madeleine, Bernhart, Eva, Plastira, Ioanna, Reicher, Helga, Leopold, Christina, Eichmann, Thomas O., Rechberger, Gerald, Madreiter-Sokolowski, Corina T., Prasch, Jürgen, Eller, Philipp, Graier, Wolfgang F., Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037060/
https://ncbi.nlm.nih.gov/pubmed/32050431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21031143
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