Hypoxia as a Therapy for Mitochondrial Disease

Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide, Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Science
Main Authors: Jain, Isha H., Zazzeron, Luca, Goli, Rahul, Alexa, Kristen, Schatzman-Bone, Stephanie, Dhillon, Harveen, Goldberger, Olga, Peng, Jun, Shalem, Ophir, Sanjana, Neville E., Zhang, Feng, Goessling, Wolfram, Zapol, Warren M., Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860742/
https://ncbi.nlm.nih.gov/pubmed/26917594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9642
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares