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Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells

Neuroendocrine (NE) cells are epithelial cells that possess many of the characteristics of neurons, including the presence of secretory vesicles and the ability to sense environmental stimuli. The normal physiologic functions of solitary airway NE cells remain a mystery. We show that mouse and human...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Shivaraju, Manjunatha, Chitta, Udbhav K., Grange, Robert M. H., Jain, Isha H., Capen, Diane, Liao, Lan, Xu, Jianming, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K., Rajagopal, Jayaraj
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312065/
https://ncbi.nlm.nih.gov/pubmed/33384370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba0629
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