CRF receptor-1 antagonism mitigates Aβ pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer’s disease (AD), but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long term safety in animal models. METHODS: To test whether anta...

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Veröffentlicht in:Alzheimers Dement
Hauptverfasser: Zhang, Cheng, Kuo, Ching-Chang, Moghadam, Setareh H., Monte, Louise, Campbell, Shannon N., Rice, Kenner C., Sawchenko, Paul E., Masliah, Eliezer, Rissman, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860182/
https://ncbi.nlm.nih.gov/pubmed/26555315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.09.007
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