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CRF receptor-1 antagonism mitigates Aβ pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer’s disease (AD), but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long term safety in animal models. METHODS: To test whether anta...

詳細記述

保存先:
書誌詳細
出版年:Alzheimers Dement
主要な著者: Zhang, Cheng, Kuo, Ching-Chang, Moghadam, Setareh H., Monte, Louise, Campbell, Shannon N., Rice, Kenner C., Sawchenko, Paul E., Masliah, Eliezer, Rissman, Robert A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860182/
https://ncbi.nlm.nih.gov/pubmed/26555315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.09.007
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