CRF receptor-1 antagonism mitigates Aβ pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer’s disease (AD), but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long term safety in animal models. METHODS: To test whether anta...

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Bibliografiske detaljer
Udgivet i:Alzheimers Dement
Main Authors: Zhang, Cheng, Kuo, Ching-Chang, Moghadam, Setareh H., Monte, Louise, Campbell, Shannon N., Rice, Kenner C., Sawchenko, Paul E., Masliah, Eliezer, Rissman, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860182/
https://ncbi.nlm.nih.gov/pubmed/26555315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.09.007
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