TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia

Fanconi Anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide s...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Zhang, Haojian, Kozono, David E, O’Connor, Kevin W, Vidal-Cardenas, Sofia, Rousseau, Alix, Hamilton, Abigail, Moreau, Lisa, Gaudiano, Emily F, Greenberger, Joel, Bagby, Grover, Soulier, Jean, Grompe, Markus, Parmar, Kalindi, D’Andrea, Alan D
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860147/
https://ncbi.nlm.nih.gov/pubmed/27053300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.002
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