TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia

Fanconi Anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide s...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Zhang, Haojian, Kozono, David E, O’Connor, Kevin W, Vidal-Cardenas, Sofia, Rousseau, Alix, Hamilton, Abigail, Moreau, Lisa, Gaudiano, Emily F, Greenberger, Joel, Bagby, Grover, Soulier, Jean, Grompe, Markus, Parmar, Kalindi, D’Andrea, Alan D
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860147/
https://ncbi.nlm.nih.gov/pubmed/27053300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.002
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