Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can cause neurodegeneration remains controversial. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-dependent, progressiv...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Lui, Hansen, Zhang, Jiasheng, Makinson, Stefanie R., Cahill, Michelle K., Kelley, Kevin W., Huang, Hsin-Yi, Shang, Yulei, Oldham, Michael C., Martens, Lauren Herl, Gao, Fuying, Coppola, Giovanni, Sloan, Steven A., Hsieh, Christine L., Kim, Charles C., Bigio, Eileen H., Weintraub, Sandra, Mesulam, Marek-Marsel, Rademakers, Rosa, Mackenzie, Ian R., Seeley, William W., Karydas, Anna, Miller, Bruce L., Borroni, Barbara, Ghidoni, Roberta, Farese, Robert V., Paz, Jeanne T., Barres, Ben A., Huang, Eric J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860138/
https://ncbi.nlm.nih.gov/pubmed/27114033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.001
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