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RNAi induced hepatotoxicity results from loss of the first synthesized isoform of miR-122 in mice
Small RNAs can be used to target and eliminate expression of virtually any disease causing gene or infectious virus, resulting in their pre-clinical and clinical development for treating disease(1). To ensure success of RNAi therapeutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860119/ https://ncbi.nlm.nih.gov/pubmed/27064447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4079 |
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