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Soluble Prion Protein and Its N-terminal Fragment Prevent Impairment of Synaptic Plasticity by Aβ Oligomers: Implications for Novel Therapeutic Strategy in Alzheimer’s Disease
The pathogenic process in Alzheimer’s disease (AD) appears to be closely linked to the neurotoxic action of amyloid-β (Aβ) oligomers. Recent studies have shown that these oligomers bind with high affinity to the membrane-anchored cellular prion protein (PrP(C)). It has also been proposed that this b...
Kaydedildi:
| Yayımlandı: | Neurobiol Dis |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860038/ https://ncbi.nlm.nih.gov/pubmed/26949218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.03.001 |
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