Soluble Prion Protein and Its N-terminal Fragment Prevent Impairment of Synaptic Plasticity by Aβ Oligomers: Implications for Novel Therapeutic Strategy in Alzheimer’s Disease

The pathogenic process in Alzheimer’s disease (AD) appears to be closely linked to the neurotoxic action of amyloid-β (Aβ) oligomers. Recent studies have shown that these oligomers bind with high affinity to the membrane-anchored cellular prion protein (PrP(C)). It has also been proposed that this b...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Scott-McKean, Jonah J., Surewicz, Krystyna, Choi, Jin-Kyu, Ruffin, Vernon A., Salameh, Ahlam I., Nieznanski, Krzysztof, Costa, Alberto C.S., Surewicz, Witold K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860038/
https://ncbi.nlm.nih.gov/pubmed/26949218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.03.001
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