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Crystal structure of human prion protein fragment reveals a motif for oligomer formation
The structural transition of the prion protein from α-helical to β-sheet rich underlies its conversion into infectious and disease-associated isoforms. Here we describe the crystal structure of a fragment from human prion protein consisting of the disulfide bond linked portions of helices 2 and 3. I...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3766960/ https://ncbi.nlm.nih.gov/pubmed/23808589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403001q |
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