Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis

BACKGROUND: Epidural fibrosis is a common complication after laminectomy. It is associated with intractable lower back pain and additional complications. To date, no study has evaluated whether the local application of rapamycin (RAPA) can inhibit fibroblast proliferation and reduce epidural scar ad...

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Publicado en:J Orthop Surg Res
Autores principales: Sun, Yu, Zhao, Shuai, Li, Xiaolei, Yan, Lianqi, Wang, Jingcheng, Wang, Daxin, Chen, Hui, Dai, Jihang, He, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859967/
https://ncbi.nlm.nih.gov/pubmed/27154399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13018-016-0391-0
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