Local genome topology can exhibit an incompletely rewired 3D-folding state during somatic cell reprogramming

Pluripotent genomes are folded in a topological hierarchy that reorganizes during differentiation. The extent to which chromatin architecture is reconfigured during somatic cell reprogramming is poorly understood. Here we integrate fine-resolution architecture maps with epigenetic marks and gene exp...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Beagan, Jonathan A., Gilgenast, Thomas G., Kim, Jesi, Plona, Zachary, Norton, Heidi K., Hu, Gui, Hsu, Sarah C., Shields, Emily J., Lyu, Xiaowen, Apostolou, Effie, Hochedlinger, Konrad, Corces, Victor G., Dekker, Job, Phillips-Cremins, Jennifer E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859942/
https://ncbi.nlm.nih.gov/pubmed/27152443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.04.004
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