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“Bivalent” regions of cytosine methylation and H3K27 acetylation suggest an active role for DNA methylation at enhancers

The role of cytosine methylation in the structure and function of enhancers is not well understood. In this study, we investigate the role of DNA methylation at enhancers by comparing the epigenomes of the HCT116 cell line and its highly demethylated derivative, DKO1. Unlike promoters, a portion of...

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Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Charlet, Jessica, Duymich, Christopher E., Lay, Fides D., Mundbjerg, Kamilla, Sørensen, Karina Dalsgaard, Liang, Gangning, Jones, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859934/
https://ncbi.nlm.nih.gov/pubmed/27153539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.033
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