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Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding

The standard 3 + 3 or “modified Fibonacci” up-and-down (MF-UD) method of dose escalation is by far the most used design in dose-finding cancer trials. However, MF-UD has always shown inferior performance when compared with its competitors regarding number of patients treated at optimal doses. A cons...

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Detalhes bibliográficos
Publicado no:Entropy (Basel)
Main Authors: Rogatko, André, Cook-Wiens, Galen, Tighiouart, Mourad, Piantadosi, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859761/
https://ncbi.nlm.nih.gov/pubmed/27156869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/e17085288
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