Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients

BACKGROUND: Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and its main metabolite, R-trans-4-OH-...

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Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Meister, Isabel, Kovac, Jana, Duthaler, Urs, Odermatt, Peter, Huwyler, Jörg, Vanobberghen, Fiona, Sayasone, Somphou, Keiser, Jennifer
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859549/
https://ncbi.nlm.nih.gov/pubmed/27152952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004700
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