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Signaling Pathway of GP88 (Progranulin) in Breast Cancer Cells: Upregulation and Phosphorylation of c-myc by GP88/Progranulin in Her2-Overexpressing Breast Cancer Cells

Her2 is a receptor tyrosine kinase overexpressed in 25% of breast tumors. We have shown that the 88 kDa autocrine growth and survival factor GP88 (progranulin) stimulated Her2 phosphorylation and proliferation and conferred Herceptin resistance in Her2-overexpressing cells. Herein, we report that GP...

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Bibliografske podrobnosti
izdano v:Breast Cancer (Auckl)
Main Authors: Kim, Wes E., Yue, Binbin, Serrero, Ginette
Format: Artigo
Jezik:Inglês
Izdano: Libertas Academica 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859449/
https://ncbi.nlm.nih.gov/pubmed/27168723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCBCR.S29371
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