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Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation
Mammalian 2-cysteine peroxiredoxins (Prxs) are susceptible to hyperoxidation by excess H(2)O(2). The cytoplasmic family member Prx2 hyperoxidizes more readily than mitochondrial Prx3 due to slower dimerization of the sulfenic acid (S(p)OH) intermediate. Four variant amino acids near the C-terminus h...
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| Vydáno v: | Biochem J |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859152/ https://ncbi.nlm.nih.gov/pubmed/26614766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150572 |
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