Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence

Innate immunity plays a central role in resolving infections by pathogens. Host survival during plague, caused by the Gram-negative bacterium Yersinia pestis, is favored by a robust early innate immune response initiated by IL-1β and IL-18. These cytokines are produced by a two-step mechanism involv...

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Vydáno v:J Biol Chem
Hlavní autoři: Ratner, Dmitry, Orning, M. Pontus A., Starheim, Kristian K., Marty-Roix, Robyn, Proulx, Megan K., Goguen, Jon D., Lien, Egil
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858993/
https://ncbi.nlm.nih.gov/pubmed/26884330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.697698
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