Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA

Virulence of Yersinia pestis in mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved across Y. pestis strains, but three, YopJ, YopT, and YpkA, are apparently...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Palace, Samantha G., Proulx, Megan K., Szabady, Rose L., Goguen, Jon D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105907/
https://ncbi.nlm.nih.gov/pubmed/29891548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00318-18
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