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Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation

Replication of the hepatitis C viral genome is catalyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase, which is a major target of antiviral drugs currently in the clinic. Prior studies established that initiation of RNA replication could be facilitated by starting with a dinuc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Jiawen, Johnson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858960/
https://ncbi.nlm.nih.gov/pubmed/26851276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708354
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