Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

BACKGROUND: Citrullination catalysed by peptidylarginine deiminases (PADs) plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and, possibly, several other inflammatory diseases. Non-physiological reducing agents such as dithiothreitol...

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Publicat a:Arthritis Res Ther
Autors principals: Damgaard, Dres, Bjørn, Mads Emil, Steffensen, Maria A., Pruijn, Ger J. M., Nielsen, Claus H.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858833/
https://ncbi.nlm.nih.gov/pubmed/27149996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1000-7
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