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Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

INTRODUCTION: Members of the peptidylarginine deiminase (PAD) family catalyse the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullination of proteins is well described in rheumatoid arthritis (RA), and hypercitrullination of proteins may be related to inflammation in g...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Damgaard, Dres, Senolt, Ladislav, Nielsen, Michael Friberg, Pruijn, Ger J, Nielsen, Claus H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298085/
https://ncbi.nlm.nih.gov/pubmed/25475141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0498-9
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