Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

INTRODUCTION: Members of the peptidylarginine deiminase (PAD) family catalyse the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullination of proteins is well described in rheumatoid arthritis (RA), and hypercitrullination of proteins may be related to inflammation in g...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Damgaard, Dres, Senolt, Ladislav, Nielsen, Michael Friberg, Pruijn, Ger J, Nielsen, Claus H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298085/
https://ncbi.nlm.nih.gov/pubmed/25475141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0498-9
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