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Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis

Xanthones are natural products present in plants and microorganisms. In plants, their biosynthesis starts with regioselective cyclization of 2,3′,4,6-tetrahydroxybenzophenone to either 1,3,5- or 1,3,7-trihydroxyxanthones, catalysed by cytochrome P450 (CYP) enzymes. Here we isolate and express CYP81A...

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Pubblicato in:Nat Commun
Autori principali: El-Awaad, Islam, Bocola, Marco, Beuerle, Till, Liu, Benye, Beerhues, Ludger
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858744/
https://ncbi.nlm.nih.gov/pubmed/27145837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11472
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