Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

IFN-α has been used for decades to treat chronic hepatitis B and C, and as an off-label treatment for some cases of hepatitis E virus (HEV) infection. TNF-α is another important cytokine involved in inflammatory disease, which can interact with interferon signaling. Because interferon-stimulated gen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Wang, Wenshi, Xu, Lei, Brandsma, Johannes H., Wang, Yijin, Hakim, Mohamad S., Zhou, Xinying, Yin, Yuebang, Fuhler, Gwenny M., van der Laan, Luc J. W., van der Woude, C. Janneke, Sprengers, Dave, Metselaar, Herold J., Smits, Ron, Poot, Raymond A., Peppelenbosch, Maikel P., Pan, Qiuwei
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858707/
https://ncbi.nlm.nih.gov/pubmed/27150018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25482
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