Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

IFN-α has been used for decades to treat chronic hepatitis B and C, and as an off-label treatment for some cases of hepatitis E virus (HEV) infection. TNF-α is another important cytokine involved in inflammatory disease, which can interact with interferon signaling. Because interferon-stimulated gen...

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Udgivet i:Sci Rep
Main Authors: Wang, Wenshi, Xu, Lei, Brandsma, Johannes H., Wang, Yijin, Hakim, Mohamad S., Zhou, Xinying, Yin, Yuebang, Fuhler, Gwenny M., van der Laan, Luc J. W., van der Woude, C. Janneke, Sprengers, Dave, Metselaar, Herold J., Smits, Ron, Poot, Raymond A., Peppelenbosch, Maikel P., Pan, Qiuwei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858707/
https://ncbi.nlm.nih.gov/pubmed/27150018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25482
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