DNA methylation and genetic polymorphisms of the Leptin gene interact to influence lung function outcomes and asthma at 18 years of age

The leptin gene (LEP) plays a regulatory role in satiety, inflammation, and allergy. Prior findings linking leptin to asthma motivated us to investigate whether DNA methylation (DNA-M) of CpG (cytosine-phosphate-guanine) sites in concert with single nucleotide polymorphisms (SNPs) of LEP can explain...

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Detalles Bibliográficos
Publicado en:Int J Mol Epidemiol Genet
Main Authors: Mukherjee, Nandini, Lockett, Gabrielle A, Merid, Simon K, Melén, Erik, Pershagen, Göran, Holloway, John W, Arshad, Syed Hasan, Ewart, Susan, Zhang, Hongmei, Karmaus, Wilfried
Formato: Artigo
Idioma:Inglês
Publicado: e-Century Publishing Corporation 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858611/
https://ncbi.nlm.nih.gov/pubmed/27186323
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