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RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases

The human genome contains six genes coding for proteins validated in vitro as specific activators of the small GTPases “Ras-related protein Ral-A” and “Ras-related protein Ral-B”, generically named Ral-guanine nucleotide exchange factors (RalGEF). Ral proteins are important contributors to Ras oncog...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: O. Santos, Adriana, Parrini, Maria Carla, Camonis, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858283/
https://ncbi.nlm.nih.gov/pubmed/27149377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154840
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