Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4–9 Deletion Mouse Model of Autism

Shank3 is a multi-domain, synaptic scaffolding protein that organizes proteins in the postsynaptic density of excitatory synapses. Clinical studies suggest that ~0.5% of autism spectrum disorder (ASD) cases may involve SHANK3 mutation/deletion. Patients with SHANK3 mutations exhibit deficits in cogn...

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Veröffentlicht in:Autism Res
Hauptverfasser: Jaramillo, Thomas C., Speed, Haley E., Xuan, Zhong, Reimers, Jeremy M., Liu, Shunan, Powell, Craig M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857590/
https://ncbi.nlm.nih.gov/pubmed/26559786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/aur.1529
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