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Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest

Cell cycle regulation is critical for chondrocyte differentiation and hypertrophy. Recently we identified the Notch signaling pathway as an important regulator of chondrocyte proliferation and differentiation during mouse cartilage development. To investigate the underlying mechanisms, we assessed t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shang, Xifu, Wang, Jinwu, Luo, Zhengliang, Wang, Yongjun, Morandi, Massimo M., Marymont, John V., Hilton, Matthew J., Dong, Yufeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857138/
https://ncbi.nlm.nih.gov/pubmed/27146698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25594
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