Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice

The prevention of organ damage and early death in young adults is a major clinical concern in sickle cell disease (SCD). However, mechanisms that control adult progression of SCD during the transition from adolescence are poorly defined with no cognate prophylaxis. Here, we demonstrate in a longitud...

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Udgivet i:JCI Insight
Main Authors: Ghosh, Samit, Ihunnah, Chibueze A., Hazra, Rimi, Walker, Aisha L., Hansen, Jason M., Archer, David R., Owusu-Ansah, Amma T., Ofori-Acquah, Solomon F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857015/
https://ncbi.nlm.nih.gov/pubmed/27158670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.81090
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