Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice

The prevention of organ damage and early death in young adults is a major clinical concern in sickle cell disease (SCD). However, mechanisms that control adult progression of SCD during the transition from adolescence are poorly defined with no cognate prophylaxis. Here, we demonstrate in a longitud...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ghosh, Samit, Ihunnah, Chibueze A., Hazra, Rimi, Walker, Aisha L., Hansen, Jason M., Archer, David R., Owusu-Ansah, Amma T., Ofori-Acquah, Solomon F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857015/
https://ncbi.nlm.nih.gov/pubmed/27158670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.81090
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