Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity. Our previous ‘synthetic nucleic acid substitution’ strategy has been successfully applied in dissecting the function of nucl...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Hwang, Candy S., Xu, Liang, Wang, Wei, Ulrich, Sébastien, Zhang, Lu, Chong, Jenny, Shin, Ji Hyun, Huang, Xuhui, Kool, Eric T., McKenna, Charles E., Wang, Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857003/
https://ncbi.nlm.nih.gov/pubmed/27060150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw220
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