Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity. Our previous ‘synthetic nucleic acid substitution’ strategy has been successfully applied in dissecting the function of nucl...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Hwang, Candy S., Xu, Liang, Wang, Wei, Ulrich, Sébastien, Zhang, Lu, Chong, Jenny, Shin, Ji Hyun, Huang, Xuhui, Kool, Eric T., McKenna, Charles E., Wang, Dong
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857003/
https://ncbi.nlm.nih.gov/pubmed/27060150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw220
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