Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity. Our previous ‘synthetic nucleic acid substitution’ strategy has been successfully applied in dissecting the function of nucl...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Hwang, Candy S., Xu, Liang, Wang, Wei, Ulrich, Sébastien, Zhang, Lu, Chong, Jenny, Shin, Ji Hyun, Huang, Xuhui, Kool, Eric T., McKenna, Charles E., Wang, Dong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857003/
https://ncbi.nlm.nih.gov/pubmed/27060150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw220
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