Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans

Despite representing an important source of genetic variation, tandem repeats (TRs) remain poorly studied due to technical difficulties. We hypothesized that TRs can operate as expression (eQTLs) and methylation (mQTLs) quantitative trait loci. To test this we analyzed the effect of variation at 484...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Quilez, Javier, Guilmatre, Audrey, Garg, Paras, Highnam, Gareth, Gymrek, Melissa, Erlich, Yaniv, Joshi, Ricky S., Mittelman, David, Sharp, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857002/
https://ncbi.nlm.nih.gov/pubmed/27060133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw219
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