Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction

The transcription factor (TF) SOX18 drives lymphatic vessel development in both embryogenesis and tumour-induced neo-lymphangiogenesis. Genetic disruption of Sox18 in a mouse model protects from tumour metastasis and established the SOX18 protein as a molecular target. Here, we report the crystal st...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Klaus, Miriam, Prokoph, Nina, Girbig, Mathias, Wang, Xuecong, Huang, Yong-Heng, Srivastava, Yogesh, Hou, Linlin, Narasimhan, Kamesh, Kolatkar, Prasanna R., Francois, Mathias, Jauch, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856986/
https://ncbi.nlm.nih.gov/pubmed/26939885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw130
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