DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330359/
https://ncbi.nlm.nih.gov/pubmed/25578969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1390
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk