DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330359/
https://ncbi.nlm.nih.gov/pubmed/25578969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1390
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