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An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation

Active DNA demethylation (ADDM) in mammals occurs via hydroxylation of 5-methylcytosine (5mC) by TET and/or deamination by AID/APOBEC family enzymes. The resulting 5mC derivatives are removed through the base excision repair (BER) pathway. At present, it is unclear how the cell manages to eliminate...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Grin, Inga, Ishchenko, Alexander A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856981/
https://ncbi.nlm.nih.gov/pubmed/26843430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw059
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