Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway

Mismatch uracil DNA glycosylase (Mug) from Escherichia coli is an initiating enzyme in the base-excision repair pathway. As with other DNA glycosylases, the abasic product is potentially more harmful than the initial lesion. Since Mug is known to bind its product tightly, inhibiting enzyme turnover,...

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Detalhes bibliográficos
Main Authors: Grippon, Seden, Zhao, Qiyuan, Robinson, Tom, Marshall, Jacqueline J. T., O’Neill, Rory J., Manning, Hugh, Kennedy, Gordon, Dunsby, Christopher, Neil, Mark, Halford, Stephen E., French, Paul M. W., Baldwin, Geoff S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074160/
https://ncbi.nlm.nih.gov/pubmed/21112870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq913
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