TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

Type I interferon (IFN) is an important component of antiviral innate immune signaling mediated by viral DNA and RNA recognition by the DNA sensor cGAS and RNA sensors RIG-I and MDA5. Activation of these DNA and RNA sensors leads to the recruitment of STING and MAVS, respectively, and converges on T...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Qin, Yunfei, Liu, Qingxiang, Tian, Shuo, Xie, Weihong, Cui, Jun, Wang, Rong-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856760/
https://ncbi.nlm.nih.gov/pubmed/26915459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.27
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